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Aplastic Anemia in a Patient Receiving Felbamate for Complex Partial Seizures Neurol 45:456-460, Pennell,P.B.,et al, 1995 See this aricle in Pubmed Article Abstract A 53-year-old woman began taking felbamate for uncontrolled complex partial seizures.Four months later,she developed fatigue and ecchymotic skin lesions.Laboratory studies revealed very severe aplastic anemia.There have been an additional nine reported cases of aplastic anemia in the setting of felbamate treatment.The association between felbamate and aplastic anemia has resulted in a joint recommendation by the US Food and Drug Administration and the manufacturer of felbamate,Carter-Wallace,Inc., for the immediate withdrawal of patients from treatment with felbamate. newabs Al18K MR imaging of a 67-year-old woman with Wernicke encephalopathy(WE)demonstrated symmetrical hyperintense lesions along the central and precentral sulci bilaterally besides the usual diencephalic and brain stem abnormalities.Postmortem examination confirmed that the lesions in the cerebral cortex were necrotizing and similar to those in typical WE.

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(click to filter results - removes previous filter) adverse drug reaction anemia anemia,aplastic anticonvulsants,untoward effects of felbamate

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